The RECEDE Study – REducing Colonoscopies in patients without significant bowEl DiseasE
Open
Professor Ramesh Arasaradnam
University Hospitals Coventry & Warwickshire NHS Trust
NIHR Health Services and Delivery Research
To investigate the diagnostic accuracy of stool faecal immunochemical testing (FIT) when used in combination with urine volatile organic compound (VOC) analysis to determine patients who do or do not have significant bowel disease, without the need for a colonoscopy.
Prospective diagnostic accuracy study
Gastroenterology
1819
Investigating people with bowel symptoms uses a test that detects traces of blood in the stools, the Faecal immunochemical Test (FIT). There are many possible reasons for positive tests. A few people have cancer. But most patients with symptoms don’t have any serious bowel disease, but have benign problems such as piles or irritable bowel syndrome. It is very difficult to diagnose on symptoms alone, those patients who have serious bowel disease and those who do not.
After a positive test, people are invited for colonoscopy – a sort of camera examination of the large bowel. Most people invited for colonoscopy don’t have cancer. Only about 5% of those with positive
FIT tests have cancer. About 25% have other bowel diseases, but most (70%) have nothing seriously wrong at all. So, they have the inconvenience and discomfort of colonoscopy but don’t get any benefit from it.
We want to try adding another test, the Volatile Organic Compound (VOC) test, to see if we can separate those with positive FIT tests who do have something wrong, from those who don’t. The VOC test uses a urine sample. Using both tests might also be better for detecting cancer.
So, we think that using both tests might not only be better for detecting cancer, but also might mean that a lot of people will avoid having to have a colonoscopy.
We will recruit 1,819 patients with bowel symptoms from hospitals in different parts of England. They will provide stool samples for FIT and urine for VOC analysis. They will all have a colonoscopy to get a definite diagnosis. Then we will look at their FIT and VOC test results to see if in future, people with both tests negative don’t need colonoscopies.
21/09/2020
30 months
Tel: 02476 966581 Email: RecedeStudyOffice@uhcw.nhs.uk
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IMPORTANT INFORMATION ON BLOOD TESTING DUE TO COVID-19
If you are experiencing symptoms associated with COVID-19, e.g. fever, loss of taste or continuous new cough, please DO NOT attend for a blood test.
Earlier this year, the Government revised the guidance on Shielding for CEV patients. All those who have been identified as CEV have been advised to follow the same guidance as everyone else, whilst potentially thinking about extra precautions you could take to reduce your chance of catching COVID-19.
Taking into account this guidance, and the evidence that most patients have now resumed having their blood tests at their usual preferred location, UHCW will no longer be providing the Shielding phlebotomy service from Monday 13 December 2021. You will need to make arrangements to get your blood tests done, as you did prior to the pandemic at locations across Coventry and Warwickshire at www.uhcw.nhs.uk/bloodtests If your specialist has requested a blood test which is due to be taken prior to Monday 13th December, you can expect it to take place at a ‘Pop-up’ clinic, as before. Any blood tests required after this date will need to be a booked appointment.
You can keep up to date with the latest advice from the Government and from UHCW on the following website: www.gov.uk/government/publications/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19/guidance-on-shielding-and-protecting-extremely-vulnerable-persons-from-covid-19
Click on the map for information about phlebotomy clinics in Coventry. You can book an appointment online at the locations in red.
Please book an appointment before attending for a blood test. Click on the ‘Book Online’ button above. Booking an appointment helps patients, their carers and family members to plan their hospital visit better, helping to reduce clinic waiting times and enabling patients to be seen much more quickly.
Location: Outpatients Department, on the ground floor. Opening hours: 8am-4.45pm, Monday to Friday (excluding bank holidays).
Children under 16 years old will need to book online here.
Please book an appointment before attending for a blood test, click on the ‘Book Online’ button above. Patients from Rugby and the surrounding areas are able to access the Friends Blood Taking Unit at the Hospital of St Cross.
Referrals for blood tests can be from GP's, practice nurses or from hospital consultants. Patients are also able to leave other samples, such as urine, which have been collected at home, at the hospital's Pathology Reception.
Location: Near Brookfield House, just off North Road - map here. Opening hours: The blood taking clinic sessions for adults and children are listed below:
Monday -Friday 7am-4:45pm Appointment only
Wednesday Evening 5pm-7pm Suspended due to COVID
Saturday Morning 7am-10pm Suspended due to COVID
April 2020 NEW - This Clinic is now by appointment. Please book an appointment before attending for a blood test. Click on the ‘Book Online’ button above.
Address: Stoney Stanton Road, Coventry CV1 4FS Location: Access is via the main doors, the Phlebotomy team are in Area A. Opening hours: Monday to Friday (excluding bank holidays). 8am–4.45pm
Glucose Tolerance Test (GTT)
Specialist Tests - There are a small number of specialist tests where blood needs to be taken on a hospital site as the sample must be transferred to the laboratory rapidly for the test to be undertaken. Click here for a list of these specialist tests and to find out more.